/* Scientific explanations: stable symbols, explicit states and readable controls. */
.mobile-occupancy{display:none}.process-legend{display:flex;flex-wrap:wrap;gap:10px 30px;font-size:10px;color:#bdcdb3;margin:0 0 24px}.process-legend>span+span{border-left:1px solid #57704f;padding-left:25px}
.species-key{font-size:10px;color:#bdcfad;letter-spacing:.8px;margin:0 0 15px}
.binding-workbench{margin-top:55px;padding-top:45px;border-top:1px solid #b9c7ad;scroll-margin-top:120px}
.binding-heading{display:grid;grid-template-columns:1fr 1fr;gap:55px;align-items:end;margin-bottom:25px}.binding-heading h3{font-size:39px;letter-spacing:-1.6px;margin:0}.binding-heading>p{max-width:470px;margin:0;color:#52664e;font-size:15px}.binding-heading .eyebrow{margin-bottom:14px}
.model-banner{font-size:12px;border:1px solid #b7c3a8;padding:15px 18px;margin-bottom:0;background:#f3f4e8}.model-banner strong{font-weight:650}.binding-layout{display:grid;grid-template-columns:1.2fr 1fr;border:1px solid #b7c3a8;border-top:0}.binding-population{background:#12392f;color:#e1ecd3;padding:28px 32px}.binding-settings{padding:30px;background:#fafaf1;min-width:0}.binding-settings label{font-size:13px}.binding-settings select{font-size:14px;min-height:48px;background:#fffef6}.binding-settings sub{line-height:0}
.reaction{display:grid;grid-template-columns:1fr 110px 1fr;align-items:center;gap:10px;padding-bottom:17px}.reaction-species{display:flex;flex-direction:column;align-items:center;text-align:center}.reaction-species>svg,.free-pair{height:80px}.reaction-species>svg{width:70px}.free-pair{display:flex;align-items:center;justify-content:center;gap:4px}.free-pair svg{width:56px;height:70px}.free-pair em{font-style:normal;font-size:21px}.reaction-species strong{font-size:21px;font-weight:500;letter-spacing:1px}.reaction-species>span{font-size:11px;color:#bed0b4}.reaction-arrows{text-align:center;display:flex;flex-direction:column;align-items:center}.reaction-arrows span{font-size:10px;color:#d0dfbf}.reaction-arrows b{font-size:46px;line-height:1.1;font-weight:400}.reaction-note{font-size:11px;color:#b6c9ac;line-height:1.6;margin:0;border-top:1px solid #41634e;padding-top:15px}
.population-heading{display:flex;justify-content:space-between;align-items:center;gap:15px;margin:27px 0 14px}.population-heading h4{font-size:15px;font-weight:500;margin:0}.population-heading>span{font-size:10px;white-space:nowrap}.population-heading i{display:inline-block;width:7px;height:7px;margin:0 4px 0 10px;border-radius:50%;border:1px solid #cfe0b9}.population-heading .legend-bound{background:#d99a68;border-color:#d99a68}
.aptamer-population{display:grid;grid-template-columns:repeat(10,1fr);gap:5px}.population-symbol{color:#a7bf9a;position:relative;border:1px solid #365c47;border-radius:5px;padding:3px 2px 15px;transition:background .35s,border-color .35s}.population-symbol svg{display:block;width:100%}.population-symbol b{position:absolute;bottom:2px;left:0;right:0;text-align:center;font-size:9px;color:#bdcdae;font-weight:500}.population-symbol.is-bound{background:#244b37;border-color:#839c64;color:#d9e9ac}.population-symbol.is-bound b{color:#f1c79d}.bound-target{opacity:0;transform:translateX(7px);transition:opacity .35s ease,transform .45s cubic-bezier(.22,1,.36,1)}.is-bound .bound-target{opacity:1;transform:translateX(0)}
.population-count{font-size:12px;margin:14px 0 4px}.symbol-note{font-size:10px;color:#b6c9ac;line-height:1.6;margin:0}.occupancy-meter{height:11px;background:#49614c;margin:23px 0 12px;border-radius:20px;overflow:hidden}.occupancy-meter>div{height:100%;width:50%;background:#e1b27e;transition:width .4s cubic-bezier(.22,1,.36,1)}.occupancy-labels{display:flex;justify-content:space-between;color:#cfddc0;font-size:12px}.occupancy-labels strong{font-size:34px;font-weight:450;color:#edf2df;letter-spacing:-1px;margin-right:5px;font-variant-numeric:tabular-nums}
.fixed-kd{display:grid;grid-template-columns:1fr auto;align-items:center;border-bottom:1px solid #cbd3bd;padding:21px 0 18px;margin-bottom:22px}.fixed-kd>span{font-size:12px}.fixed-kd>strong{font-size:27px;font-weight:500;letter-spacing:-.8px}.fixed-kd small{grid-column:1/-1;margin:3px 0 0;font-size:10px}.binding-settings output{display:block;font-size:24px;font-weight:500;margin-top:8px;font-variant-numeric:tabular-nums}.binding-settings input[type=range]{height:44px;padding:0;border:0;accent-color:#47653e;background:transparent;cursor:pointer}.range-ends{display:flex;justify-content:space-between;font-size:10px;color:#596a50}#concentration-scale{font-size:10px;color:#596a50;line-height:1.6;margin:9px 0 17px}.binding-presets{display:grid;grid-template-columns:repeat(3,1fr);gap:7px}.binding-presets button{border:1px solid #8f9f7a;background:transparent;border-radius:3px;font-size:12px;min-height:44px;padding:7px;color:#274730}.binding-presets button[aria-pressed=true]{background:#d9e7b2;border-color:#77915b}.model-explanation{font-size:13px;min-height:48px;line-height:1.6;margin:18px 0}.model-details{font-size:11px;border-top:1px solid #cbd3bd;padding-top:14px}.model-details summary{cursor:pointer;min-height:38px;font-size:12px}.model-details p{margin:10px 0;line-height:1.7}.model-details a{text-decoration:underline;text-underline-offset:3px;display:inline-block;padding:5px 0}.motion-button{min-height:44px;background:transparent;border:0;border-bottom:1px solid currentColor;color:inherit;padding:9px 0;font-size:11px}.binding-settings>.motion-button{margin-top:14px}.workbench-boundary{font-size:11px;color:#586b50;max-width:1000px;margin:17px 0 0}
.process-story{padding:65px 0 30px}.process-story .workflow-header{margin-bottom:30px}.process-story .workflow-controls{margin-bottom:28px}.process-status{display:grid;grid-template-columns:80px 1fr;column-gap:20px;align-items:baseline;margin-bottom:25px}.process-status>span{font-size:11px;color:#bed19e;letter-spacing:2px}.process-status h3{font-size:29px;margin:0 0 8px}.process-status p{grid-column:2;font-size:13px;color:#bdcdb3;line-height:1.7;margin:0}.process-panel[hidden]{display:none!important}.experiment-flow{display:grid;grid-template-columns:repeat(3,1fr);gap:24px}.selection-panel .experiment-flow{grid-template-columns:repeat(4,1fr)}.experiment-node{position:relative;border:1px solid #506e52;border-radius:4px;padding:21px;background:#193d30;min-width:0;animation:experiment-arrive .45s both;animation-delay:calc(var(--step)*.05s)}.experiment-node:not(:last-child)::after{content:'→';position:absolute;right:-21px;top:48%;color:#c4d7aa;font-size:18px}.node-number{font-size:10px;color:#a9c28e;letter-spacing:2px}.experiment-node h4{font-size:17px;line-height:1.35;font-weight:500;min-height:46px;margin:12px 0 9px}.node-visual{height:125px;display:flex;align-items:center;justify-content:center;flex-direction:column;color:#d9e9b8;margin-bottom:15px}.node-visual>svg{width:120px;height:95px}.experiment-node p{font-size:12px;line-height:1.75;color:#b9cdb0;margin:0}.question-symbol{font-family:Georgia,serif;font-size:76px;font-weight:400;line-height:1}.library-symbols{display:grid;grid-template-columns:repeat(3,1fr);width:125px}.library-symbols svg{height:36px;width:36px}.sequence-1{color:#9bb8ae}.sequence-2{color:#dfb486}.exposure-pair{display:flex;align-items:center;width:100%}.exposure-pair>svg{width:33%;height:80px}.partition-lanes{display:flex;width:100%;gap:7px}.partition-lanes>span{width:50%;display:flex;flex-direction:column;align-items:center}.partition-lanes svg{height:60px;width:50px}.partition-lanes b{font-size:9px;font-weight:400;text-align:center;line-height:1.4}.partition-lanes>span:last-child{opacity:.65;border-left:1px dashed #78926e}.copy-symbols{display:flex}.copy-symbols svg{width:31px;height:56px}.diagram-tag{font-size:10px;margin-top:7px;color:#b9cdb0;text-align:center}.individual-candidates{display:flex;gap:28px}.individual-candidates>span{display:flex;flex-direction:column;align-items:center;font-size:12px}.individual-candidates svg{width:47px;height:65px}.dilution-series{display:flex;gap:11px;height:105px;padding-top:6px}.dilution-series>span{display:flex;flex-direction:column;align-items:center;gap:7px}.dilution-series i{height:63px;width:22px;border:1px solid #bdd09e;border-top-width:3px;border-radius:0 0 8px 8px;position:relative;overflow:hidden}.dilution-series i::after{content:'';position:absolute;bottom:0;left:1px;right:1px;height:75%;background:#d99a68;opacity:var(--density)}.dilution-series b{font-size:10px;font-weight:400}.readout-sheet{width:100%;font-size:10px;max-width:220px}.readout-sheet>div{border-bottom:1px solid #526f50;padding:7px 0;display:flex;justify-content:space-between;gap:10px}.readout-sheet>div:first-child{color:#e2d5a9}.readout-sheet span{color:#b4c9a7}.review-symbol{font-family:Georgia,serif;font-size:50px;line-height:1.5}.comparison-symbol{display:flex;gap:15px;align-items:center}.comparison-symbol>span{border:1px solid #d7ac7f;border-radius:50%;width:40px;height:40px;display:grid;place-content:center;font-size:16px}.comparison-symbol>span:last-child{border-style:dashed;border-color:#afc49a}.comparison-symbol em{font-size:11px;font-style:normal}.process-output{border-left:2px solid #b8cd94;padding:12px 18px;background:#1d4232;color:#d2dfc4;font-size:12px;line-height:1.7;margin:25px 0 0;min-height:66px}.process-navigation{display:flex;align-items:center;justify-content:space-between;gap:20px;padding:21px 0 0}.process-navigation button{min-height:44px;border:1px solid #708c66;background:transparent;color:#e4ecd8;border-radius:3px;padding:9px 14px;font-size:12px}.process-navigation button:disabled{opacity:.35}.process-navigation>span{font-size:10px;color:#b6c8a9}.process-story .workflow-foot{border-top:1px solid #426149;margin-top:24px;align-items:center}.process-story .workflow-foot .motion-button{min-height:44px;padding:9px 0}.process-story .workflow-foot>span{font-size:10px}
@keyframes experiment-arrive{from{opacity:.4;transform:translateY(7px)}to{opacity:1;transform:translateY(0)}}
.motion-paused .experiment-node{animation:none!important;opacity:1}.offscreen .experiment-node{animation-play-state:paused}
@media(max-width:1050px){.binding-layout{grid-template-columns:1fr 1fr}.binding-population{padding:25px 22px}.aptamer-population{grid-template-columns:repeat(5,1fr);gap:7px}.population-symbol svg{height:44px}.population-heading{display:block}.population-heading>span{display:block;margin-top:7px}.population-heading i:first-child{margin-left:0}.reaction{grid-template-columns:1fr 80px 1fr;gap:4px}.reaction-species>span{font-size:10px}.free-pair{gap:0}.free-pair svg{width:42px}.selection-panel .experiment-flow{grid-template-columns:repeat(2,1fr)}.selection-panel .experiment-node:nth-child(2)::after{display:none}.selection-panel .experiment-node:nth-child(2){border-bottom-color:#a7bd87}}
@media(max-width:800px){.binding-workbench{margin-top:40px;padding-top:30px}.binding-heading{grid-template-columns:1fr;gap:18px}.binding-heading h3{font-size:31px}.binding-heading>p{font-size:14px}.model-banner{font-size:11px;line-height:1.7;padding:13px 16px}.binding-layout{grid-template-columns:1fr}.binding-population{padding:24px 20px}.reaction{grid-template-columns:1fr 86px 1fr}.reaction-species>span{font-size:10px}.population-heading{display:flex;gap:8px}.population-heading h4{font-size:14px}.population-heading>span{margin:0;font-size:9px}.population-heading i{margin-left:6px}.aptamer-population{grid-template-columns:repeat(5,1fr)}.population-symbol svg{height:48px}.binding-settings{padding:25px 20px}.binding-settings select{font-size:16px}.model-explanation{min-height:44px}.process-status{grid-template-columns:1fr;gap:8px}.process-status p{grid-column:1}.process-status h3{font-size:27px}.experiment-flow,.selection-panel .experiment-flow{grid-template-columns:1fr;gap:22px}.experiment-node{display:grid;grid-template-columns:90px 1fr;column-gap:17px;padding:18px;min-height:170px}.node-number{grid-column:2}.experiment-node h4{grid-column:2;min-height:0;margin:6px 0 8px;font-size:17px}.node-visual{grid-column:1;grid-row:1/4;height:115px;align-self:center;margin:0}.experiment-node p{grid-column:2;font-size:12px}.experiment-node:not(:last-child)::after,.selection-panel .experiment-node:nth-child(2)::after{display:block;content:'↓';right:auto;left:45%;top:auto;bottom:-24px}.node-visual>svg{width:90px}.library-symbols{width:87px}.library-symbols svg{width:28px;height:32px}.copy-symbols{display:grid;grid-template-columns:1fr 1fr}.copy-symbols svg{height:40px}.exposure-pair{flex-wrap:wrap;justify-content:center}.exposure-pair>svg{height:45px;width:45px}.exposure-pair>svg:last-child{width:80px}.partition-lanes{gap:3px}.partition-lanes svg{width:40px}.partition-lanes b{font-size:8px}.individual-candidates{gap:5px}.individual-candidates svg{width:40px}.dilution-series{gap:5px}.dilution-series i{width:17px}.dilution-series b{font-size:8px}.readout-sheet{font-size:8px}.readout-sheet>div{gap:4px}.diagram-tag{font-size:8px}.comparison-symbol{gap:7px}.comparison-symbol>span{width:29px;height:29px;font-size:12px}.process-navigation{gap:10px;flex-wrap:wrap}.process-navigation>span{order:3;width:100%;text-align:center}.process-navigation button{font-size:11px;padding:8px 10px}.process-story .workflow-foot>span{max-width:55%}.process-story .workflow-header{margin-bottom:24px}}
@media(max-width:360px){.reaction{grid-template-columns:1fr 67px 1fr;gap:0}.reaction-arrows span{font-size:8px}.reaction-species>span{font-size:8px}.free-pair svg{width:34px}.reaction-species>svg{width:55px}.population-heading{display:block}.population-heading>span{margin-top:6px}.occupancy-labels strong{font-size:27px}.binding-presets button{font-size:11px}.experiment-node{grid-template-columns:74px 1fr;column-gap:12px;padding:15px}.node-visual>svg{width:74px}.library-symbols{width:74px}.library-symbols svg{width:24px}.readout-sheet{font-size:7px}.individual-candidates svg{width:32px}.dilution-series{gap:3px}.dilution-series i{width:15px}}
@media(prefers-reduced-motion:reduce){.binding-workbench *,.process-story *{animation:none!important;transition:none!important}.experiment-node{opacity:1;transform:none}}
@media(max-width:800px){.mobile-occupancy{display:grid;grid-template-columns:1fr auto;align-items:center;gap:10px;margin-top:22px;padding:13px 0;border-top:1px solid #becbac}.mobile-occupancy>span{font-size:11px;color:#52664e}.mobile-occupancy>strong{font-size:28px;font-weight:500;letter-spacing:-1px}.mobile-meter{grid-column:1/-1;height:9px;background:#d0d8c1;border-radius:10px;overflow:hidden}.mobile-meter>div{height:100%;width:50%;background:#5e7e48;transition:width .4s ease}.binding-settings .model-explanation{margin:10px 0 16px}.process-legend{font-size:9px;gap:5px 12px}.process-legend>span+span{padding-left:0;border:0}.population-heading>span{font-size:8px}}
@media(max-width:800px){#process-panel-2 .experiment-node:last-child,#process-panel-1 .experiment-node:nth-child(3){display:flex;flex-direction:column}.experiment-node .readout-sheet{font-size:11px;max-width:260px}#process-panel-2 .experiment-node:last-child .node-visual{width:100%;height:145px;margin-bottom:12px}#process-panel-1 .experiment-node:nth-child(3) .node-visual{width:100%;height:110px;margin-bottom:12px}.partition-lanes b{font-size:11px}.partition-lanes svg{height:66px;width:52px}}
.dilution-series i::before{content:'';position:absolute;bottom:0;left:1px;right:1px;height:75%;background:#718e7b;opacity:.3}

/* Finish pass: stronger hierarchy, comfortable labels and precise controls. */
.binding-heading h3{font-weight:450;line-height:1.16}.binding-heading>p{line-height:1.8}.model-banner{font-size:12px;line-height:1.8;border-radius:5px 5px 0 0}.binding-layout{border-radius:0 0 5px 5px;overflow:hidden}.species-key{font-size:11px;letter-spacing:.7px}.reaction-species>span{font-size:12px}.reaction-arrows span{font-size:11px}.reaction-note{font-size:12px;color:#c1d1b8}.population-heading{flex-wrap:wrap}.population-heading h4{font-size:16px}.population-heading>span{font-size:11px}.population-count{font-size:13px}.symbol-note{font-size:11px;color:#bbceb1}.population-symbol{border-color:#53704d}.population-symbol b{font-size:10px}.occupancy-labels strong,.fixed-kd>strong,.binding-settings output{font-variant-numeric:tabular-nums}.fixed-kd>strong{font-size:30px}.fixed-kd small{font-size:11px}.range-ends,#concentration-scale{font-size:11px}.binding-settings label{font-weight:600}.binding-settings input[type=range]{appearance:none;-webkit-appearance:none;border-radius:6px;outline-offset:3px}.binding-settings input[type=range]::-webkit-slider-runnable-track{height:5px;border-radius:6px;background:linear-gradient(to right,#547441 0%,#547441 var(--range-progress),#d0d8c2 var(--range-progress),#d0d8c2 100%)}.binding-settings input[type=range]::-webkit-slider-thumb{appearance:none;-webkit-appearance:none;width:23px;height:23px;background:#214d38;border:4px solid #fafaf1;border-radius:50%;box-shadow:0 0 0 1px #547441;margin-top:-9px}.binding-settings input[type=range]::-moz-range-track{height:5px;border-radius:6px;background:#d0d8c2}.binding-settings input[type=range]::-moz-range-progress{height:5px;background:#547441}.binding-settings input[type=range]::-moz-range-thumb{width:17px;height:17px;background:#214d38;border:3px solid #fafaf1;border-radius:50%;box-shadow:0 0 0 1px #547441}.binding-presets button{font-size:13px;transition:background .15s ease,border-color .15s ease}.binding-presets button[aria-pressed=true]{font-weight:650;border-color:#52733b;box-shadow:inset 0 -2px #52733b}.binding-presets button:hover:not([aria-pressed=true]){background:#edf1e1}.model-explanation{font-size:14px;line-height:1.7}.model-details{font-size:12px}.model-details summary{font-size:13px;min-height:44px;display:list-item;padding:6px 0}.model-details a{min-height:35px}.workbench-boundary{font-size:12px;line-height:1.8}.binding-workbench .motion-button,.process-story .motion-button{border:1px solid #728764;border-radius:24px;padding:9px 14px;min-height:44px;font-size:11px;text-decoration:none;white-space:nowrap;transition:background .15s ease}.motion-button::before{content:'Ⅱ';display:inline-block;min-width:17px;margin-right:5px}.motion-button[aria-pressed=true]::before{content:'▷'}.motion-button:disabled::before{content:'';display:none}.binding-workbench .motion-button:hover{background:#eaf0dc}.process-story .motion-button:hover{background:#244c38}.process-legend{font-size:11px;color:#c4d4ba;line-height:1.8}.process-status>span{font-size:12px}.process-status p{font-size:14px}.process-story .stage-button{font-size:15px;transition:background .18s ease,color .18s ease}.process-story .stage-button.active{box-shadow:inset 0 -3px #97b56a}.process-story .stage-button span{font-size:11px}.experiment-node{border-color:#5a7857;animation-duration:.32s;animation-delay:calc(var(--step)*.035s)}.experiment-node h4{font-size:18px;font-weight:550}.experiment-node p{font-size:13px;color:#c2d3b9;line-height:1.8}.node-number{font-size:11px}.diagram-tag{font-size:11px;color:#c2d3b9}.partition-lanes b{font-size:11px}.readout-sheet{font-size:12px}.dilution-series b{font-size:11px}.process-output{font-size:13px;line-height:1.8;border-left-width:3px}.process-navigation button{min-height:46px;padding:10px 16px;font-size:13px}.process-navigation button:hover:not(:disabled){background:#284f3b}.process-navigation>span,.process-story .workflow-foot>span{font-size:11px}.process-story .workflow-foot{gap:25px}
@media(max-width:800px){.binding-population{padding:24px 18px}.reaction-species>span{font-size:10px}.reaction-arrows span{font-size:10px}.reaction-note{font-size:11px}.population-heading h4{font-size:15px}.population-heading>span{font-size:10px;line-height:1.7}.symbol-note{font-size:11px}.population-heading{margin-top:24px}.population-symbol b{font-size:10px}.fixed-kd{padding:18px 0}.binding-settings{padding:25px 18px}.binding-presets{gap:6px}.binding-presets button{font-size:12px;min-height:46px}.mobile-occupancy>span{font-size:12px;line-height:1.5;max-width:190px}.mobile-occupancy>strong{font-size:31px}.model-explanation{font-size:13px}.model-details summary{font-size:12px}.workbench-boundary{font-size:11px}.process-story .stage-button{font-size:13px;min-height:60px}.process-legend{font-size:10px;gap:5px 15px}.process-status h3{font-size:28px;line-height:1.2}.process-status p{font-size:14px}.experiment-node{padding:19px 16px}.experiment-node h4{font-size:18px}.experiment-node p{font-size:13px}.node-number{font-size:10px}.diagram-tag{font-size:10px}.dilution-series b{font-size:9px}.process-output{font-size:12px}.process-navigation button{font-size:12px;min-height:46px;padding:10px 12px}.process-navigation>span{font-size:10px}.process-story .workflow-foot{align-items:flex-start;flex-wrap:wrap;gap:14px}.process-story .workflow-foot>span{max-width:100%;font-size:10px;line-height:1.7}.process-story .motion-button{font-size:11px}}
@media(max-width:360px){.reaction-species>span{font-size:9px}.reaction-arrows span{font-size:9px}.population-heading{display:block}.population-heading>span{margin-top:6px}.binding-presets button{font-size:11px}.fixed-kd>strong{font-size:28px}.mobile-occupancy>span{font-size:11px;max-width:150px}.experiment-node{grid-template-columns:74px 1fr;column-gap:12px;padding:17px 13px}.experiment-node h4{font-size:17px}.readout-sheet{font-size:11px}}